تاثیر عصاره هیدرو- الکلی دانه خرنوب(Ceratonia siliqua L.) بر فاکتورهای عملکردی کلیوی و الکترولیت‌های سرم در موش صحرایی نر دیابتی

Diabetes Mellitus is the most important human metabolic disease which leads to hyperglycemia and hyperlipidemia. Hyperglycemia can give rise to disorder in kidney. In the present study, we attempted to investigate the effect of hydro-alcoholic seed extract of Ceratonia siliqual. on the blood levels of creatinine,uric acid,BUN,Na+,K+and Ca2+in diabetic male rats. Materials and Methods: In this experimental study, fifty-six adult male Wistar rats each weighing 210-220g was randomly divided into seven groups of eight. These groups include: control group which left untreated sham group which received distilled water treated control group received only 600mg/kg seed extract diabetic control group getting only Streptozotocine and three experimental groups 1, 2 and 3 receiving 150,300 and 600mg/kg extract respectively. Diabetes was induced by intraperitoneal injection(60mg/kg) of STZ. Following induction of diabetes, the extract dosages were administered to the rats by gavageing method for sixteen days. Serum levels creatinin,uric acid,BUN,Na+,K+and Ca2+were measured by outoanalyzer. The data were analyzed by SPSS-18 software using ANOVA test. The results were expressed as Mean±SEM and a P≤0.05 was set as significant value. Results: In experimental group 1 concentration of creatinine and BUN decreased significantly, while K+ level was declined in experimental groups 1 and 3. The serum level of uric acid in experimental group1 showed a considerable elevation. In addition, in experimental groups 1 and 3 concentration of Na+ increased significantly. There were no significant differences in Ca2+ concentration among various groups. Conclusion: Ceratonia siliqua seed extract can improve distractive effects of diabetes on kidney.